The signs and symptoms of anaphylaxis may begin within seconds to minutes of exposure to or contact with an offending stimulus, but in certain situations symptoms may develop more than 30 minutes after exposure.1,5
An isolated anaphylactic reaction is referred to as a uniphasic reaction.5 Biphasic reactions often occur 8 to 12 hours after the immediate reaction. Biphasic reactions can occur up to 72 hours after resolution of initial reactions; a need for a second dose cannot be predicted.2 Some protracted reactions can last up to 32 hours, despite aggressive treatment.1
Symptoms of anaphylaxis may include any of the following1:
Epinephrine and oxygen are the most important therapeutic agents to be administered during an anaphylactic reaction.1 Immediate recognition of the signs and symptoms of anaphylaxis is crucial.
The appropriate dose of Epinephrine should be given promptly at the onset of apparent anaphylaxis.1 If a patient has previously had an anaphylactic reaction, he or she may already be carrying an auto-injector.2 Twinject auto-injectors contain 2 doses of epinephrine. One dose is for a uniphasic (occurring immediately) reaction. The next step is to call 911 to ensure emergency services are on the way. The second dose is to be administered for an acute reaction in which a single dose is not enough to reverse symptoms, or to be used in the event of a biphasic or protracted reaction.
Twinject auto-injectors also are available in 2 dosing strengths. The Twinject 0.15 mg is for those weighing between 33 and 66 pounds (approximately 15 to 30 kilograms) and the Twinject 0.3 mg is for those who weigh 66 pounds (approximately 30 kilograms) or more.
Twinject also may be prescribed as a Two-Pack, which includes 2 Twinject auto-injectors and a demonstrator. Storing Twinject auto-injectors in multiple locations helps ensure that protection is always within reach—at school, at home, and on the go.Click here for Twinject administration instructions.