Twinject® - Easy to Train and Simple to Use

Although epinephrine is a very effective treatment, an anaphylactic reaction can be so severe and prolonged that 1 dose of epinephrine will not reverse the symptoms. Even mild reactions sometimes require more than 1 injection of epinephrine, and a second dose may be needed within minutes of the first. Unfortunately, only 16% of patients carry 2 doses of epinephrine.^1-3

Since emergency help may be far away or delayed, it is important to keep at least 2 doses of epinephrine on hand at all times. Twinject^® is the only auto-injector that provides a back-up dose of epinephrine in 1 easy to train, simple to use device. Twinject makes it easy to stay prepared—without having to carry a second auto-injector.

Learn more about new Twinject here.

REFERENCES 1. Webb L, Greene E, Lieberman PI. Anaphylaxis: a review of 593 cases. J Allergy Clin Immunol. 2004;113(suppl 1):S240. Abstract 857. 2. Korenblat P, Lundie MJ, Dankner RE, Day JH. A retrospective study of epinephrine administration for anaphylaxis: how many doses are needed? Allergy Asthma Proc. 1999;20:383-386. 3. Varghese M, Lieberman P. Factors affecting the use of automatic epinephrine injectors (AEIs) [abstract]. AAAAI Annual Meeting 2006. Miami, FL; March 3-7, 2006. 4. Zitt M. Patient education and awareness about the use of epinephrine auto-injectors. Presented at: ACAAI Annual Meeting 2006. Philadelphia, PA; November 9-15, 2006.

IMPORTANT SAFETY INFORMATION ABOUT TWINJECT: Twinject is indicated in the emergency treatment of severe allergic reaction (type I) including anaphylaxis to stinging insects and biting insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as anaphylaxis to unknown substance or exercise-induced anaphylaxis.

Since the dose of epinephrine delivered from Twinject 0.15 mg is fixed at 0.15 mg, the physician should consider other forms of injectable epinephrine if doses lower than 0.15 mg are felt to be necessary (eg, patients who weigh less than 15 kilograms [approximately 33 pounds]).

Twinject should only be injected into the anterolateral aspect of the thigh. Accidental injection into the hands or feet may result in loss of blood flow to the affected area and should be avoided. DO NOT INJECT INTO BUTTOCK. DO NOT INJECT INTRAVENOUSLY.

Epinephrine should be administered with caution to patients with cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In patients with coronary insufficiency or ischemic heart disease, epinephrine may precipitate or aggravate angina pectoris as well as produce ventricular arrhythmias. It should be recognized that the presence of these conditions is not a contraindication to epinephrine administration in an acute life-threatening situation. Adverse reactions to epinephrine include transient, moderate anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties.

Twinject is designed as an emergency supportive therapy only and is not a replacement or substitute for immediate medical care. Please see complete prescribing information for more details.