The Twinject auto-injector delivers epinephrine rapidly and easily. Epinephrine,
the active ingredient in Twinject, is the most effective treatment available for anaphylaxis. It is administered by way of injection through the skin into
the thigh, and begins working immediately. Epinephrine helps you breathe
by relaxing constricted airways in the lungs. It also reverses dropping
blood pressure by constricting small blood vessels.
The simple assurance of a second dose
Epinephrine is very effective in the emergency treatment of anaphylaxis.
But up to 1 out of every 3 reactions will require more than 1 dose of epinephrine.1 There is no way to predict how severe a reaction will be, yet only 16% of people carry more than 1 dose of epinephrine.2,3 For this reason, it is very important to have a second, prepared dose
of epinephrine nearby during an anaphylactic reaction.
Twinject is the only available auto-injector that provides 2 doses of
epinephrine in 1 device. With portable and lightweight Twinject, you can:
- Avoid the hassle of keeping track of 2 separate auto-injectors and
expiration dates
- Replace bulky travel packs with 1 slim carrying case
Each Twinject comes with:
- Simple, easy to follow first-dose directions printed on the side of the auto-injector
- A slim, crush-resistant case that tucks easily into purses, pockets,
and backpacks protects drug from sunlight
- A permanently attached wrap label with clear, step-by-step directions
for the second dose
- Thin, 25-gauge needle
Available in 2 dosing strengths
- Twinject 0.15 mg is for those weighing between 33 and 66 pounds (approximately
15-30 kilograms)
- Twinject 0.3 mg is indicated for those who weigh 66 pounds (approximately
30 kilograms) or more
Twinject Two-Pack for protection at home and away
Twinject may also be prescribed as a Two-Pack, which includes 2 Twinject
auto-injectors. Storing Twinject auto-injectors in multiple locations
helps ensure that protection is always within reach—at school, at
home, and on the go. The Twinject Two-Pack also includes a take-home practice
device to help caregivers and family members learn how to give a Twinject
injection. If you currently have a Twinject single prescription, ask your
doctor if the Twinject Two-Pack is right for you.
REFERENCES 1. Korenblat P, Lundie MJ, Dankner RE,
Day JH. A retrospective study of epinephrine administration for anaphylaxis:
How many doses are needed? Allergy Asthma Proc. 1999;20:383-386.
2. Joint Task Force on Practice Parameters; AAAI; ACAAI; JCAAI. The diagnosis
and management of anaphylaxis: an updated practice parameter. J Allergy
Clin Immunol. 2005;115(suppl):S483-S523. 3. Varghese M, Lieberman P. Factors affecting the use of automatic epinephrine injectors (AEIs) [abstract]. AAAAI Annual Meeting 2006. Miami, FL; March 3-7, 2006.
IMPORTANT SAFETY INFORMATION ABOUT TWINJECT: Twinject is indicated in
the emergency treatment of severe allergic reaction (type I) including
anaphylaxis to stinging insects and biting insects, allergen immunotherapy,
foods, drugs, diagnostic testing substances, and other allergens, as well
as anaphylaxis to unknown substance or exercise-induced anaphylaxis.
Since the dose of epinephrine delivered from Twinject 0.15 mg is fixed
at 0.15 mg, the physician should consider other forms of injectable epinephrine
if doses lower than 0.15 mg are felt to be necessary (eg, patients who
weigh less than 15 kilograms [approximately 33 pounds]).
Twinject should only be injected into the anterolateral aspect of the
thigh. Accidental injection into the hands or feet may result in loss
of blood flow to the affected area and should be avoided. DO NOT INJECT
INTO BUTTOCK. DO NOT INJECT INTRAVENOUSLY.
Epinephrine should be administered with caution to patients with cardiac
arrhythmias, coronary artery or organic heart disease, or hypertension.
In patients with coronary insufficiency or ischemic heart disease, epinephrine
may precipitate or aggravate angina pectoris as well as produce ventricular
arrhythmias. It should be recognized that the presence of these conditions
is not a contraindication to epinephrine administration in an acute life-threatening
situation. Adverse reactions to epinephrine include transient, moderate anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties.
Twinject is designed as an emergency supportive therapy only and is not
a replacement or substitute for immediate medical care.
